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Background: Atherosclerosis is a progressive disease of large and medium-sized arteries characterized by the accumulation of lipids and fibrous elements in the large arteries. Cholesterol-enriched diet causes age-related macular ... Results: Model rabbits fed with ten weeks of high-cholesterol diet developed significant progression of atherosclerosis. In this report, we describe the histological characteristics of spontaneous glaucoma in a rabbit fed a high-cholesterol diet. Those in exercise training groups ran on a treadmill at 0.88 km/h for up to 40 minutes per day, 5 days per week for the same period of time as the diet feeding. The chemical Therefore, it is generally recommended that feeding rabbits a 0.3~0.5% . group fed with routine diet (group NC) and high cholesterol diet group (group CD) fed a 2% cholesterol diet with 0.24 ppm copper in the drinking water for 12 weeks. Animals were randomly divided into four groups of eight animals each for 60 days as follows: normal diet, hypercholesterolemic diet (1% cholesterol), hypercholesterolemic diet (1% cholesterol) + sesame seed (10%), and hypercholesterolemic diet (1% cholesterol) + sesame oil (5&# . Cholesterol-fed rabbit is an animal model which has been used for the study of atherosclerosis. Gene and protein expressions of E-sel, ICAM-1, VCAM-1 and MCP-1 in atherosclerotic Experimental group 1: the diet plus desiccated whole thyroid gland. Glutathione levels, glutathione peroxidase, and glutathione transferase activities decreased significantly, Cholesterol deposition in the intima of coronary arteries was observed in the S-HC group, but the formation of an atherosclerotic plaque was not observed. New Zealand white rabbits were fed one of three diets, a reference diet with no cholesterol added (NC), a high cholesterol diet (1 g/100 g, HC) and a HC diet supplemented with 2 g/100 g hawthorn fruit powder (HC-H). Thoracic aortas were isolated for functional and immunohistochemical analyses. 68, No. It is interesting to demonstrate that macrophage infiltration also occurred in the adipose tissue of 3%-HFD-fed rabbits, suggesting that . CiteSeerX - Document Details (Isaac Councill, Lee Giles, Pradeep Teregowda): The effects of polarized-light therapy (PLT) on high-cholesterol diet (HCD)-induced hypercholesterolemia and atherosclerosis were investigated in comparison with that of lovastatin in rabbits. 50 Scopus citations. Pulse-chase experiment with [3H]glucosamine or [3H]leucine showed that fibronectin secreted by the aorta explants from rabbits fed high fat-high cholesterol diets incorporated an increased amount of radioactivity. Note extensive atheromatous plaques induced by HCD and marked attenuation by 20 min PLT, in comparison with intact features in rabbits fed normal diet. Therefore, the present study . Yesim Negis, Nurgül Aytan, Nesrin Özer, Esra Ogru, Roksan Libinaki, Robert Gianello, Angelo Azzi, Jean Marc Zingg. 29 33 34 35 Conversely, reducing the level of dietary cholesterol has been reported to produce lesions containing large numbers of SMCs, cholesterol clefts, and necrotic debris, a . Atherosclerotic lesions of the rabbits receiving P277 treatment and fed with high cholesterol diet increased significantly compared with those of the . Bioscience, Biotechnology, and Biochemistry: Vol. Moreover, only RGNK reduced hepatic cholesterol and cholesteryl ester transfer protein activity levels. A group of twenty eight male rabbits was divided into four subgroups; a normal diet group, a high-cholesterol diet group, a high-cholesterol diet with 1 % (w/w . New Zealand white rabbits were fed with a normal diet, high cholesterol (1.3%), lard oil (3%) diet (HCD) with or without 0.5 or 1% MWE for 10 weeks. ˚e plasma levels of TC and TG were measured. Seven others were fed the high cholesterol diet continuously and killed at intervals up to 382 days. The rabbits were fed with a normal diet or a high cholesterol diet for 10 weeks. Table 1: Serum lipid profiles in normal and high cholesterol diet-fed rabbits treated with simvastatin and Prosopis farcta root extract for 30 days Abstract—The early effects of hypercholesterolemia on leukocyte-endothelium interaction were studied in vivo in the rabbit mesenteric microcirculation.Rabbits fed a 0.5% high-cholesterol (HC) diet showed elevated plasma cholesterol levels during the 1 to 2 weeks of HC feeding (P<0.001 versus control diet-fed rabbits).Intravital microscopy of mesenteric venules revealed that leukocyte . White rabbits fed on a high-cholesterol diet. In the latter 4-week phase of the cholesterol-free diet, one group received intravenous trehalose solution at a dose of 350 mg/kg, three times per week. The beneficial effect of Spirulina (Spirulina platensis) on tissue lipid peroxidation and oxidative DNA damage was tested in the hypercholesterolemic New Zealand White rabbit model. Levels of blood lipids, serum tumour-necrosis factor-alpha (TNF-α) and serum interleukin-1beta (IL-1β) were detected at the end of the sixth and tenth week. After a 2-week adaptation period, rabbits were randomly assigned to five equal groups: control (normal) group fed on standard a diet, HCD control group fed on HCD (1 % cholesterol), and three groups fed on HCD and treated with P. eldarica nut in three different doses (50, 100 and 200 mg/kg/day). Effects of For changes in lipid indices, the high cholesterol diet fed rabbits (PC) showed significantly increased in TC, LDL-C, HDL-C, and TG levels compared to normal animals (NC). Honey Improves Sperm Parameters in High Cholesterol Diet-Fed Male Rabbits. the ApoE −/− mice were started on a high-fat, high-cholesterol (HFHC) diet of 4.5 kcal/g, 20% fat, and 1.25% cholesterol (D12108C, Research Diet Inc, New Brunswick, NJ) for 20 to 36 weeks with and without treatment with D-PDMP (5 and 10 mg/kg) and compared with control mice fed only a chow diet and placebo mice fed HFHC plus vehicle. Because the two groups were matched for TPC, we High intake of cholesterol and saturated fat were also long been suspected to increase the risk for AMD. Three other rabbits were fed the high cholesterol diet for 14 days and then killed at intervals up to 70 days. Table 1: Serum lipid profiles in normal and high cholesterol diet-fed rabbits treated with simvastatin and Prosopis farcta root extract for 30 days ˚e rabbits were fed a normal chow diet o%h cholesterol diet for 16 weeks. Male rabbits were served a high-cholesterol (0.5%, w/w) diet or high-cholesterol diet supplemented with either . RG and RGNK significantly reduced increased serum triglycerides levels and aortic plaque area in a hypercholesterol diet fed rabbits. 10, pp. The effects of cinnamaldehyde (CIN), a commonly consumed food flavor, against high-cholesterol diet (HCD)-induced vascular damage in rabbits were evaluated. The rabbits were divided ran-domly into two groups. Hazelnut Oil Administration Reduces Aortic Cholesterol Accumulation and Lipid Peroxides in the Plasma, Liver, and Aorta of Rabbits Fed a High-cholesterol Diet. It was concluded by gross visual grading, The control group of rabbits was only given a high cholesterol diet. After hypercholesterolemia was induced by feeding a high cholesterol (0.5%) diet (HCD) for 4 weeks, then HCD supplemen … In rabbits, it is known that inherited glaucoma occurs in the New Zealand white rabbit and other breeds2,3. Atherosclerotic lesions of the rabbits receiving P277 treatment and fed with high cholesterol diet increased significantly compared with those of the rabbits receiving PBS treatment and the same diet. The rabbits were randomly divided into 5 groups (): Group 1: control rabbits fed with standard diet for 12 weeks; Group 2: rabbits fed with 2% high cholesterol diet (HCD) for 12 weeks; Group 3: rabbits fed with 2% HCD for 8 weeks and treatment with simvastatin (10 mg/kg) for 4 weeks; Group 4: rabbits fed with 2% HCD for 8 weeks and treatment . Animals in high-cholesterol diet groups were fed 2 % cholesterol rabbit chow for 2, 4, or 6 weeks. edly reduced in transgenic rabbits expressing high levels of human LCAT (17). Rabbits were classified into four groups: control, nilotinib, HC, and HC + nilotinib groups. At the end of 60 days, the serum . o. The levels of triglyceride, cholesterol and low-density lipoprotein cholesterol (LDL-C) were lower in the serum of rabbits fed HCD plus MWE than in the serum of rabbits fed HCD. A high cholesterol diet (0.5% cholesterol) was fed to the NZW rabbit for 12 weeks. Monatepil maleate significantly accelerated the clearance of radioactivity from the blood after intravenous injection of low-density lipoprotein (LDL) labeled . However, by 12 weeks the plasma cholesterol levels in both groups were almost identical. Animals in high-cholesterol diet groups were fed 2% cholesterol rabbit chow for 2, 4, or 6 wk. We investigated the antiatherogenic effect of kefiran on rabbits fed a high-cholesterol diet. Animals and diet Totally 17 New Zealand rabbits (3.8-4 kg) were used during the experiments. Rabbits in the normal group were fed a regular chow diet, while rabbits in the control and Fc-CETP 6 groups were fed the HFC diet (chow supplemented with 5% lard and 0.25% cholesterol). All experimental procedures were conducted after ap-proval of the study by the Institutional Animal Care and Use Rabbits fed a diet containing up to 2% cholesterol showed a rapid rise in plasma cholesterol, which can exceed 2000 mg/dL. We analyzed the serum triglyceride, LDL‐cholesterol, and HDL‐cholesterol concentrations at 0 weeks, 4 weeks, 8 weeks and 12 weeks. In group B (n=15) the ani-mals were fed with 2% high cholesterol diet (T2030, Harlan laboratories SRL, Udine, Italy). Rabbits were randomly distributed in four groups (eight each) as the following: group I (control), fed with standard rabbit chow; group II (high-cholesterol diet, HCD), fed with 1 % cholesterol-enriched chow for 4 weeks; group III (HCD-flavocoxid), fed with 1 % cholesterol-enriched chow and treated with flavocoxid (20 mg/kg/day) orally for 4 . In high cholesterol diet-fed rabbits, monatepil maleate (30 mg/kg, p.o., once daily for 9 weeks) showed a prophylactic effect against increases in total cholesterol and beta-lipoprotein. without exercise training and the high-cholesterol diet groups with or without exercise training. The initiating events of the disease are similar to those in humans. RG and RGNK significantly reduced increased serum triglycerides levels and aortic plaque area in a hypercholesterol diet fed rabbits. Three control animals were maintained on normal chow diet and killed after 100 days. Although, the HDL level decreased in the group III and IV rabbits as compared to the high cholesterol diet group animals, but not statistically significant. Plasma lipids and body weight were measured every 4 weeks. Male New Zealand rabbits (n = 24) were allocated to four groups at random: control, fed with standard rabbit chow; CIN, fed with standard diet and administered CIN; HCD, fed with 1% cholesterol-enriched diet; and HCD-CIN, fed with HCD and . fed and the cholesterol-fed rabbit models of atheroscle-rosis, in the present study we examined the lipoprotein profiles and the atherosclerotic lesions in the entire aorta of rabbits fed a semisynthetic diet enriched in casein and in rabbits fed a cholesterol-supplemented diet. Therefore, the present study . Totally 16 Japanese White Rabbits (JWR) were randomly divided into 2 groups including normal control group fed with routine diet (group NC) and high cholesterol diet group (group CD) fed a 2% cholesterol diet with 0.24 ppm copper in the drinking water for 12 weeks. The basic values as well as the absolute and relative responses of cardiovascular parameters produced by the carotid stimulation did not show any significant differences between normal and cholesterol-fed rabbits. Rabbits in the normal group were fed a regular chow diet, while rabbits in the control and Fc-CETP 6 groups were fed the HFC diet (chow supplemented with 5% lard and 0.25% cholesterol). A possible explanation for this is that high cholesterol diet with 3% dietary fat in rabbits is insufficient for cholesterol absorption, which in turn leads to mobilization of internal adipose tissue . Adult male New Zealand white Rabbits were fed with a high-fat diet containing 1% cholesterol for 8 weeks followed by a cholesterol-free diet for the next 4 weeks. The effects of eicosapentaenoic acid ethylester (EPA-E) at daily doses of 3 and 30 mg/kg (p.o.) The objective of this current study was to investigate the possible hypolipidemic and antioxidative effects of dandelion root and leaf in rabbits fed with a high-cholesterol diet. After 12 wk … In rabbits fed a high-cholesterol diet, we evaluated the effects of the combination therapy on atherosclerotic plaques, lipid profiles, blood glucose levels, liver and kidney functions. on vascular lesions and changes in blood components were investigated in rabbits fed with a 1% cholesterol diet for 12 weeks and partly compared with those given 30 mg/kg/day (p.o.) The objective of this study was to evaluate the influence of ingested l-arginine, l-citrulline, and antioxidants (vitamins C and E) on the progression of atherosclerosis in rabbits fed a high-cholesterol diet. Male white rabbits were fed a high cholesterol diet supplemented with red ginseng (RG) or red ginseng plus nattokinase (RGNK). By the end of the eighth week, blood and tissue samples were obtained for biochemical, histological, immunohistochemical, and in vitro analyses. of ticlopidine. Data are expressed as the . Compared with the control, levels of blood lipids, TNF-α,IL-1β and MDA increased markedly in serum of model rabbits, while SOD levels decreased. Short-term feeding of dietary cholesterol in the rabbit (≥2%) yields high levels of circulating cholesterol, resulting in macrophage-derived foam-cell lesions. The descending thoracic aortae of rabbits fed either normal diet, a high cholesterol diet for 2-5 wk (hypercholesterolemic, HC), or a high cholesterol diet for 6 mo (atherosclerotic, AS) were perfused in a bioassay organ chamber with physiologic buffer containing indomethacin. All of the rabbits were fed a high cholesterol diet which resulted in the high blood levels of cholesterol. Hypercholesterolemia was induced by feeding male New Zealand white rabbits with 1 % cholesterol in diet for 2 weeks and . After 2 weeks of the high-cholesterol diet, some rabbits were excluded because of their very high (>1000 mg/dL) or . In the present study, the rabbits fed with normal standard diet or high cholesterol diet were immunized with P277 or PBS emulsified in incomplete Freund's adjuvant 4 times at 4-week intervals. lesterol diet (LRC4 containing 1% cholesterol, Oriental Yeast Co., Ltd.) for 4 weeks; and (3) long- term high cholesterol diet (L- HC) group: fed a 1% cholesterol diet for 12 weeks from the age of 6 weeks. Each animal was fed 100 g of the diet per day during the study period and allowed free access to tap water. The present study aimed to investigate the anti-hyperlipidemic effects of sesame in a high-fat fed rabbit model. Each animal was fed 100 g of the diet per day during the study period and allowed free access to tap water. Representative findings of the aorta of high-cholesterol diet (HCD)-fed rabbits (n=8) treated with lovastatin (0.002%) or 5 min or 20 min polarized-light therapy (PLT). This response can be exacerbated if extra saturated fat is added to the diet, increasing both the plasma cholesterol level and the extent of vascular lesions [ 25 ]. Accumulation of total cholesterol (TC), cholesteryl esters (CE), triacylglycerols (TG) and free fatty acids (FFA) in the aorta of rabbits fed a reference diet without addition of cholesterol (NC), a high cholesterol diet (1.0 g/100 g, HC) and a high cholesterol diet supplemented with 2.0 g/100 g hawthorn fruit powder (HC-H). Moreover, only RGNK reduced hepatic cholesterol and cholesteryl ester transfer protein activity levels. Rabbits were fed a normal diet for 12 weeks (N group) or a diet containing high cholesterol (1%) for 4 weeks (S-HC group) and 12 weeks (L-HC group). The fatty diet caused a marked impairment of endothelium-dependent vasorelaxation in isolated thoracic aorta and blood flow in rabbit ear artery in vivo , the development of atheromatous . Female rabbits fed a standard diet enriched with 2% (wt/wt) cholesterol for 12 wk exhibited 10-fold increases in total serum cholesterol concentrations (mean ± SE) from 64 ± 7 mg/dl in controls (n = 6) to 644 ± 106 mg/dl in cholesterol-fed rabbits (n = 6, P < 0.05). The effect of tocopheryl phosphates on atherosclerosis progression in rabbits fed with a high cholesterol diet. The animals of group A (n=2) were fed with normal chow. Rabbits fed a high cholesterol diet experienced a significant increase in plasma adenosine 3', 5'-monophosphate (cyclic AMP), which was simultaneous with the increase in plasma cholesterol. 8), which are seldom seen in humans. Methods: Male New Zealand White rabbits were fed a 0.5% cholesterol diet without (control group, n = 7) or with kefiran (kefiran group, n = 8) for eight weeks. Figure 1. 1 , 2 In a large number of studies rabbits are used for testing the effectiveness of new drugs, food constituents and foodstuff and their impact on the progression and/or regression . Because the cholesterol-fed rabbit is the classic model for the study of diet-induced atherosclerosis (18), we have tested the hypothesis that overexpression of LCAT in cholesterol-fed rabbits would not only increase the HDL Forty-eight male New Zealand white rabbits were assigned into 6 groups: Control (C): commercial pellet; CH: commercial . To study the pathophysiological role of cyclophilin A in atherosclerosis, we used the NZW rabbits. The TC was increased 12-fold in the first four weeks, and continued to increase a further 1.8 times by week 8. status in rabbits fed a high-cholesterol (HC) diet. Abstract Effect of Vildagliptin on Atherosclerosis Progression in High Cholesterol -Fed Male Rabbits. Additionally, a number of proteins related to lipid metabolism and scavenger receptor mRNA expressions were evaluated by Western blotting and . The content of cyclic AMP in atherosclerotic lesion areas of rabbit aortic intima-media was significantly higher (0.24 picomole per microgram of DNA) than that in adjacent nonlesion areas or in aortic . Adult male New Zealand white Rabbits were fed with a high‐fat diet containing 1% cholesterol for 8 weeks followed by a cholesterol‐free diet for the next 4 weeks. At the end of the 12- week feeding period, after 14 h of fasting, the rabbits were deeply anesthetized with sodium pentobarbital (Kyoritsu . Epidemiological studies correlated high plasma cholesterol levels with high incidence of AD, and feeding rabbits with a diet rich in cholesterol has been shown to induce AD-like pathology in rabbit brain. We wanted to investigate the effect of HO on lipid levels and prooxidant-antioxidant status in rabbits fed a high-cholesterol (HC) diet. The results were obtained from 10 rabbits with cholesterol diet and 8 rabbits with normal diet. We evaluated alterations of fatty acid composition, by the GC-MS method, while 4β-, 25-, and 27-hydroxycholesterol and 7-ketocholesterol levels by means of LC-MS/MS in high cholesterol diet-fed rabbits. The extract in the dosages of 50, 100, 200 mg was . ˚e plasma lipid levels in rabbits. Although, the HDL level decreased in the group III and IV rabbits as compared to the high cholesterol diet group animals, but not statistically significant. Therefore, the present study investigated the independent effect of diet intervention on atherosclerotic plaque and the cross‑linking of collagen in cholesterol‑fed rabbits. Magnetic resonance spectroscopy (MRS) and structural image of rabbit brain were performed by using a 3 Tesla (T) MRI scanner with an 8 channel Rabbit coil. In the latter 4‐week phase of the cholesterol‐free diet, one group received intravenous trehalose solution at a dose of 350 mg/kg, three times per week. Rabbits were fed either a regular diet or an HC-enriched diet for 8 weeks. After 30 days, different groups of rabbits were treated with the ethanol-soluble fraction of E. grandiflorus (10, 30, and 100 mg/kg, p. Research output: Contribution to journal › Article › peer-review. The present study examined the hypolipidemic activity of hawthorn fruit. humans than that of rodents, rabbits fed a simple high choles‑ terol diet have become the most popular animal model for the study of atherosclerosis(23,24). An HC diet caused significant increases in lipids and lipid peroxide levels in the plasma, liver, and aorta together with histopathological atherosclerotic changes in the aorta. The aim of this trial was to determine the antioxidative effects of the citrus bioflavonoid, naringin, a potent cholesterol-lowering agent, compared to the cholesterol-lowering drug, lovastatin, in rabbits fed a high cholesterol diet. Overconsumption of a high-energy diet has a negative impact on sperm motility, morphology, vitality and concentration. Such high plasma cholesterol (exceeding 2000 mg/dl or 51.8 mmol/L) is never seen in human hypercholesterolemic patients. Aortic atherosclerotic lesions along with cellular components, collagen fibers, matrix . After 4 weeks on these diets, the rabbits fed the diet high in both NaCl and cholesterol had significantly increased plasma cholesterol levels compared to those receiving cholesterol treatment alone. An HC diet caused significant increases in lipids and lipid peroxide levels in the plasma, liver, and aorta together with histopathological atherosclerotic changes in the aorta. cholesterol diet group (Table 1). Additionally, a number of proteins related to lipid metabolism and scavenger receptor mRNA expressions were evaluated by Western blotting and . Moreover, the atherosclerotic lesions in rabbits fed cholesterol diets consist almost completely of foam cells (Fig. On gel filtration, fibronectin synthesized by controls and cholesterol-fed rabbit resolved into four fractions. However, no obvious lesions were found in the two groups of rabbits fed with the normal standard diet. cholesterol diet group (Table 1). All rabbits were initially fed a normal diet for one week and then randomly divided into a hypercholesterolemic control group (n = 7, 1% high cholesterol diet) and two treatment groups (n = 7, 1% high cholesterol diet along with 1% dandelion leaf and root, respectively). Experimental group 2: the diet plus thyroxin or T4 (Synthroid). Rabbits were fed a high-cholesterol diet (0.5% cholesterol) of up to 120 g/day. 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